Role of av Integrins in Adenovirus Cell Entry and Gene Delivery†
نویسنده
چکیده
INTRODUCTION .......................................................................................................................................................725 IN VITRO AND IN VIVO EVIDENCE THAT aV INTEGRINS PROMOTE ADENOVIRUS CELL ENTRY......................................................................................................................................................726 ROLE OF DYNAMIN, ACTIN, AND CELL SIGNALING IN ADENOVIRUS ENTRY...................................728 ROLE OF aV INTEGRINS IN ADENOVIRUS-MEDIATED ENDOSOME DISRUPTION AND GENE DELIVERY ..............................................................................................................................................729 STRUCTURE OF A FUNCTION-BLOCKING MONOCLONAL ANTIBODY COMPLEXED WITH ADENOVIRUS ........................................................................................................................................729 STRUCTURE OF INTEGRIN aVb5 BOUND TO ADENOVIRUS......................................................................731 OTHER VIRAL PATHOGENS THAT USE INTEGRINS FOR INFECTION...................................................731 CONCLUSIONS AND FUTURE DIRECTIONS....................................................................................................732 ACKNOWLEDGMENTS ...........................................................................................................................................732 REFERENCES ............................................................................................................................................................732
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